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Korean J Thorac Cardiovasc Surg 2000; 33(8): 613-622

Published online August 5, 2000

Copyright © Journal of Chest Surgery.

Evaluation of Cardioprotective Effects of DelNido Cardioplegia

Seok Jeoung Woo, M.D.*, Bong Hyun Chang, M.D.**, Kyu Tae Kim, M.D.**

*Department of Emergency Medicine, Dong-A university Hospital, **Department of Thoracic and Cardiovascular Surgery, Kyungpook University Hospital

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: The aim of this study is to define the cardioprotective effects(functional and metabolic) of newly developed DelNido cardioplegic solution(containing plasma solution, mannitol, magnesium and lidocaine).

Material and Method: This study assessed the function of rat hearts after intermittent infusion of DelNido cardioplegia with different preserving methods(Air or Icebox) for 2hours and perfusing the hearts on a Langendorff apparatus. Heart rate, left ventricular developed pressure(LVDP) and coronary flow, were measured at pre-ischemic, post-reperfusion 15min, 30min and 45min. Coronary flow was standardized to dry heart weight. Each weight was weighted to calculate water content. Creatine kinase-MB isoenzyme release was measured and ultrastructural assessment was done with electron microscopes.
Result: DelNido group was better than St, Thomas group and Icebox group was better than Room-air group.
Conclusion: DelNido cardioplegia have better myocardial protective effets than St. Thomas cardioplegia when they were preserved in the Room-air. But we can not tell the difference between Delnido cardioplegia with Air preserving method and St. Thomas cardioplegia with Icebox.

(Korean Thorac Cardiovasc Surg 2000;33:613-22)

Keywords: Cardioplegic solution, Myocandial protection

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Original

Korean J Thorac Cardiovasc Surg 2000; 33(8): 613-622

Published online August 5, 2000

Copyright © Journal of Chest Surgery.

Evaluation of Cardioprotective Effects of DelNido Cardioplegia

Seok Jeoung Woo, M.D.*, Bong Hyun Chang, M.D.**, Kyu Tae Kim, M.D.**

*Department of Emergency Medicine, Dong-A university Hospital, **Department of Thoracic and Cardiovascular Surgery, Kyungpook University Hospital

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: The aim of this study is to define the cardioprotective effects(functional and metabolic) of newly developed DelNido cardioplegic solution(containing plasma solution, mannitol, magnesium and lidocaine).

Material and Method: This study assessed the function of rat hearts after intermittent infusion of DelNido cardioplegia with different preserving methods(Air or Icebox) for 2hours and perfusing the hearts on a Langendorff apparatus. Heart rate, left ventricular developed pressure(LVDP) and coronary flow, were measured at pre-ischemic, post-reperfusion 15min, 30min and 45min. Coronary flow was standardized to dry heart weight. Each weight was weighted to calculate water content. Creatine kinase-MB isoenzyme release was measured and ultrastructural assessment was done with electron microscopes.
Result: DelNido group was better than St, Thomas group and Icebox group was better than Room-air group.
Conclusion: DelNido cardioplegia have better myocardial protective effets than St. Thomas cardioplegia when they were preserved in the Room-air. But we can not tell the difference between Delnido cardioplegia with Air preserving method and St. Thomas cardioplegia with Icebox.

(Korean Thorac Cardiovasc Surg 2000;33:613-22)

Keywords: Cardioplegic solution, Myocandial protection

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