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J Chest Surg

Published online May 27, 2021

Copyright © Journal of Chest Surgery.

Huge Pulmonary Sclerosing Pneumocytoma with Endobronchial Invasion: A Case Report with a Literature Review

Hyun Soo Lee, M.D.1,* , Jina Kim, M.D.2,* , Duk Hwan Moon, M.D.1 , Chul Hwan Park, M.D.2 , Tae Joo Jeon, M.D., Ph.D.3 , Sungsoo Lee, M.D., Ph.D.1 , Yoon Jin Cha, M.D., Ph.D.4

Departments of 1Thoracic and Cardiovascular Surgery, 2Radiology and the Research Institute of Radiological Science, 3Nuclear medicine, and 4Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea

Correspondence to:Yoon Jin Cha
Tel 82-2-2019-2797
Fax 82-2-3463-2103
E-mail YOONCHA@yuhs.ac
ORCID
https://orcid.org/0000-0002-5967-4064
*These two authors contributed equally to this work.

Received: February 16, 2021; Revised: April 6, 2021; Accepted: April 30, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pulmonary sclerosing pneumocytoma (PSP) is a tumor of pneumocytic origin that is classified as a benign neoplasm. To date, aggressive behavior of this tumor has rarely been reported. Here, we describe a case of a 56-year-old woman with a huge, 19-cm PSP that resulted in mediastinal shift and showed microscopic endobronchial invasion and necrosis. The differential diagnosis included malignant mesenchymal tumors, such as solitary fibrous tumor; however, PSP was confirmed based on the characteristic thyroid transcription factor 1 positivity and membranous expression of Ki-67 on immunohistochemical staining of tumor cells.

Keywords: Pulmonary sclerosing hemangioma, Computed tomography, Immunohistochemistry

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J Chest Surg

Published online May 27, 2021

Copyright © Journal of Chest Surgery.

Huge Pulmonary Sclerosing Pneumocytoma with Endobronchial Invasion: A Case Report with a Literature Review

Hyun Soo Lee, M.D.1,* , Jina Kim, M.D.2,* , Duk Hwan Moon, M.D.1 , Chul Hwan Park, M.D.2 , Tae Joo Jeon, M.D., Ph.D.3 , Sungsoo Lee, M.D., Ph.D.1 , Yoon Jin Cha, M.D., Ph.D.4

Departments of 1Thoracic and Cardiovascular Surgery, 2Radiology and the Research Institute of Radiological Science, 3Nuclear medicine, and 4Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea

Correspondence to:Yoon Jin Cha
Tel 82-2-2019-2797
Fax 82-2-3463-2103
E-mail YOONCHA@yuhs.ac
ORCID
https://orcid.org/0000-0002-5967-4064
*These two authors contributed equally to this work.

Received: February 16, 2021; Revised: April 6, 2021; Accepted: April 30, 2021

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pulmonary sclerosing pneumocytoma (PSP) is a tumor of pneumocytic origin that is classified as a benign neoplasm. To date, aggressive behavior of this tumor has rarely been reported. Here, we describe a case of a 56-year-old woman with a huge, 19-cm PSP that resulted in mediastinal shift and showed microscopic endobronchial invasion and necrosis. The differential diagnosis included malignant mesenchymal tumors, such as solitary fibrous tumor; however, PSP was confirmed based on the characteristic thyroid transcription factor 1 positivity and membranous expression of Ki-67 on immunohistochemical staining of tumor cells.

Keywords: Pulmonary sclerosing hemangioma, Computed tomography, Immunohistochemistry

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