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| No. | Article Type | Article Title | Article Page |
|---|---|---|---|
| 1 | Basic Research | Poor Prognosis of Grade 2 Spread Through Air Spaces in Neuroendocrine Tumors | 101 - 107 |
| 2 | Clinical Research | Evaluation of a Smart After-Care Program for Patients with Lung Cancer: A Prospective, Single-Arm Pilot Study | 108 - 117 |
| 3 | Clinical Research | Evolution of Process and Outcome Measures during an Enhanced Recovery after Thoracic Surgery Program | 118 - 125 |
| 4 | Clinical Research | An Overview of Surgical Treatment of Thymic Epithelial Tumors in Korea: A Retrospective Multicenter Analysis | 126 - 142 |
| 5 | Clinical Research | Prediction of 6-Month Mortality Using Pre-Extracorporeal Membrane Oxygenation Lactate in Patients with Acute Coronary Syndrome Undergoing Veno-Arterial-Extracorporeal Membrane Oxygenation | 143 - 150 |
| 6 | Clinical Research | Surgical Outcomes of Cor Triatriatum Sinister: A Single-Center Experience | 151 - 157 |
| 7 | Clinical Research | Postcardiotomy Extracorporeal Membrane Oxygenation Support in Patients with Congenital Heart Disease | 158 - 167 |
| 8 | Case Report | First Case of Esophagectomy Using a Robotic Single-Port System for Laryngo-Esophagectomy | 168 - 170 |
| 9 | Case Report | A Complication of Diaphragm Repair Using a Gore-Tex (Expanded Polytetrafluorethylene) Membrane: A Case Report | 171 - 173 |
| 10 | Case Report | A Case Report of Resection of a Mediastinal Paraganglioma: Why All the Fuss? | 174 - 176 |
| 11 | Case Report | Mitral Valve Repair for Barlow's Disease with Mitral Annular and Subvalvular Calcification: A Case Report | 177 - 179 |
| 12 | Case Report | Left Ventricular Enlargement Procedure in a Patient with Diffuse-Type Hypertrophic Cardiomyopathy: A Case Report | 180 - 182 |
| 13 | Case Report | Nuss Procedure for Surgical Stabilization of Anterior Flail Chest with Mechanical Ventilation Weaning Failure: A Case Report | 183 - 187 |
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J Chest Surg
Published online April 20, 2022
Copyright © Journal of Chest Surgery.
Jeong Moon Lee, M.D.1 
, Woohyun Jung, M.D.2 , Sungwon Yum, B.S.2 , Jeong Hoon Lee, Ph.D.3 , Sukki Cho, M.D., Ph.D.2,4
1Department of Thoracic and Cardiovascular Surgery, Wonkwang University School of Medicine, Iksan; 2Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seongnam; 3Division of Biomedical Informatics, Seoul National University Biomedical Informatics, Seoul National University College of Medicine; 4Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Seoul, Korea
Correspondence to:Sukki Cho
Tel 82-31-787-7132
Fax 82-31-787-4050
E-mail skcho@snubh.org; tubincho@snu.ac.kr
ORCID
https://orcid.org/0000-0002-9309-8865
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Studies of the prognostic role of circulating tumor cells (CTCs) in early-stage non-small cell lung cancer (NSCLC) are still limited. This study investigated the prognostic power of CTCs from the pulmonary vein (PV), peripheral blood (PB), and bone marrow (BM) for postoperative recurrence in patients who underwent curative resection for NSCLC.
Methods: Forty patients who underwent curative resection for NSCLC were enrolled. Before resection, 10-mL samples were obtained of PB from the radial artery, blood from the PV of the lobe containing the tumor, and BM aspirates from the rib. A microfabricated filter was used for CTC enrichment, and immunofluorescence staining was used to identify CTCs.
Results: The pathologic stage was stage I in 8 patients (20%), II in 15 (38%), III in 14 (35%), and IV in 3 (8%). The median number of PB-, PV-, and BM-CTCs was 4, 4, and 5, respectively. A time-dependent receiver operating characteristic curve analysis showed that PB-CTCs had excellent predictive value for recurrence-free survival (RFS), with the highest area under the curve at each time point (first, second, and third quartiles of RFS). In a multivariate Cox proportional hazard regression model, PB-CTCs were an independent risk factor for recurrence (hazard ratio, 10.580; 95% confidence interval, 1.637?68.388; p<0.013).
Conclusion: The presence of ≥4 PB-CTCs was an independent poor prognostic factor for RFS, and PV-CTCs and PB-CTCs had a positive linear correlation in patients with recurrence.
Keywords: Circulating tumor cells, Non-small-cell lung carcinoma, Pulmonary veins, Bone marrow, Peripheral blood
J Chest Surg
Published online April 20, 2022
Copyright © Journal of Chest Surgery.
Jeong Moon Lee, M.D.1 , Woohyun Jung, M.D.2 , Sungwon Yum, B.S.2 , Jeong Hoon Lee, Ph.D.3 , Sukki Cho, M.D., Ph.D.2,4
1Department of Thoracic and Cardiovascular Surgery, Wonkwang University School of Medicine, Iksan; 2Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Seongnam; 3Division of Biomedical Informatics, Seoul National University Biomedical Informatics, Seoul National University College of Medicine; 4Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Seoul, Korea
Correspondence to:Sukki Cho
Tel 82-31-787-7132
Fax 82-31-787-4050
E-mail skcho@snubh.org; tubincho@snu.ac.kr
ORCID
https://orcid.org/0000-0002-9309-8865
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Studies of the prognostic role of circulating tumor cells (CTCs) in early-stage non-small cell lung cancer (NSCLC) are still limited. This study investigated the prognostic power of CTCs from the pulmonary vein (PV), peripheral blood (PB), and bone marrow (BM) for postoperative recurrence in patients who underwent curative resection for NSCLC.
Methods: Forty patients who underwent curative resection for NSCLC were enrolled. Before resection, 10-mL samples were obtained of PB from the radial artery, blood from the PV of the lobe containing the tumor, and BM aspirates from the rib. A microfabricated filter was used for CTC enrichment, and immunofluorescence staining was used to identify CTCs.
Results: The pathologic stage was stage I in 8 patients (20%), II in 15 (38%), III in 14 (35%), and IV in 3 (8%). The median number of PB-, PV-, and BM-CTCs was 4, 4, and 5, respectively. A time-dependent receiver operating characteristic curve analysis showed that PB-CTCs had excellent predictive value for recurrence-free survival (RFS), with the highest area under the curve at each time point (first, second, and third quartiles of RFS). In a multivariate Cox proportional hazard regression model, PB-CTCs were an independent risk factor for recurrence (hazard ratio, 10.580; 95% confidence interval, 1.637?68.388; p<0.013).
Conclusion: The presence of ≥4 PB-CTCs was an independent poor prognostic factor for RFS, and PV-CTCs and PB-CTCs had a positive linear correlation in patients with recurrence.
Keywords: Circulating tumor cells, Non-small-cell lung carcinoma, Pulmonary veins, Bone marrow, Peripheral blood
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