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J Chest Surg

Published online February 21, 2024

Copyright © Journal of Chest Surgery.

Fetal Lung Interstitial Tumor: A Comprehensive Case Study with an Emphasis on Next-Generation Sequencing

Yoo Jin Jung , M.D.1,*, Seongyeon Jung , M.D.2,*, Jiwon Koh , M.D., Ph.D.2, Jaemoon Koh , M.D., Ph.D.2, Yoon Kyung Jeon , M.D., Ph.D.2, Sung-Hye Park , M.D., Ph.D.2, Eun Na Kim , M.D., Ph.D.2,†, Chang Hyun Kang , M.D., Ph.D.1,†

Departments of 1Thoracic and Cardiovascular Surgery and 2Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea

Correspondence to:Chang Hyun Kang
Tel 82-2-2072-3010
Fax 82-2-764-3664
E-mail chkang@snu.ac.kr
ORCID
https://orcid.org/0000-0002-1612-1937

Eun Na Kim
Tel 82-2-2072-1735
Fax 82-2472-7898
E-mail hk1997@snu.ac.kr
ORCID
https://orcid.org/0000-0003-2992-7881

*These authors contributed equally to this work as co-first authors.
These authors contributed equally to this work as corresponding authors.

Received: November 6, 2023; Revised: December 10, 2023; Accepted: December 26, 2023

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Fetal lung interstitial tumor (FLIT), which is characterized by immature interstitial cells resembling the fetal lung parenchyma of 20 to 24 weeks of gestation, is a rare respiratory neoplasm. This study presents the first reported FLIT in Korea. It also aims to refine the diagnostic method of FLIT and increase the accuracy of prognostic assessment by using next-generation sequencing to check for anaplastic lymphoma receptor tyrosine kinase (anaplastic lymphoma kinase) gene rearrangement. Although the initial prognosis for FLIT has been promising since its first report in 2010, certain pathological features are associated with poorer outcomes. Therefore, achieving an accurate diagnosis of FLIT is crucial for avoiding unnecessary treatments beyond surgical resection.

Keywords: Fetal lung interstitial tumor, Next generation sequencing, Differential diagnosis, Case reports

Article

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J Chest Surg

Published online February 21, 2024

Copyright © Journal of Chest Surgery.

Fetal Lung Interstitial Tumor: A Comprehensive Case Study with an Emphasis on Next-Generation Sequencing

Yoo Jin Jung , M.D.1,*, Seongyeon Jung , M.D.2,*, Jiwon Koh , M.D., Ph.D.2, Jaemoon Koh , M.D., Ph.D.2, Yoon Kyung Jeon , M.D., Ph.D.2, Sung-Hye Park , M.D., Ph.D.2, Eun Na Kim , M.D., Ph.D.2,†, Chang Hyun Kang , M.D., Ph.D.1,†

Departments of 1Thoracic and Cardiovascular Surgery and 2Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea

Correspondence to:Chang Hyun Kang
Tel 82-2-2072-3010
Fax 82-2-764-3664
E-mail chkang@snu.ac.kr
ORCID
https://orcid.org/0000-0002-1612-1937

Eun Na Kim
Tel 82-2-2072-1735
Fax 82-2472-7898
E-mail hk1997@snu.ac.kr
ORCID
https://orcid.org/0000-0003-2992-7881

*These authors contributed equally to this work as co-first authors.
These authors contributed equally to this work as corresponding authors.

Received: November 6, 2023; Revised: December 10, 2023; Accepted: December 26, 2023

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Fetal lung interstitial tumor (FLIT), which is characterized by immature interstitial cells resembling the fetal lung parenchyma of 20 to 24 weeks of gestation, is a rare respiratory neoplasm. This study presents the first reported FLIT in Korea. It also aims to refine the diagnostic method of FLIT and increase the accuracy of prognostic assessment by using next-generation sequencing to check for anaplastic lymphoma receptor tyrosine kinase (anaplastic lymphoma kinase) gene rearrangement. Although the initial prognosis for FLIT has been promising since its first report in 2010, certain pathological features are associated with poorer outcomes. Therefore, achieving an accurate diagnosis of FLIT is crucial for avoiding unnecessary treatments beyond surgical resection.

Keywords: Fetal lung interstitial tumor, Next generation sequencing, Differential diagnosis, Case reports

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